Oral And Maxillofacial Manifestations Of Covid-19 - Integrative Literature Review
Manifestações Orais E Maxilofaciais Da Covid-19 – Revisão Integrativa Da Literatura
DOI:
https://doi.org/10.29327/25149.50.1-6Keywords:
Oral manifestations, Covid-19, Signs and symptomsAbstract
Scientific evidence suggests that SARS-CoV-2 is present in the oral tissues in the initial phase of contamination as the main viral reservoir. Besides the oral cavity being the main means of spread, it also becomes a common location of clinical manifestations during the onset and evolution of the disease. The objective was to evaluate the literature about the oral and maxillofacial clinical manifestations arising from Covid-19 contamination. This is an integrative literature review of the databases Latin American and Caribbean Literature on Health Sciences (Lilacs), Scientific Electronic Library Online (Scielo) and BBO Dentistry, of articles published between 2019 and 2022 that portrayed the theme of the study. Initially, the search for the descriptors was conducted individually, then, the crossings were performed using the Boolean operator "AND" and, subsequently, the three descriptors were crossed together. The inclusion criteria were articles published in Portuguese, English and Spanish, published and indexed in the databases, starting in 2019 - year of the emergence of Covid-19 and that portrayed the theme of the study. The exclusion criteria were articles published before 2019, articles outside the chosen databases, and articles that ran away from the theme of the study. During the study, 28 articles were selected from all the cited criteria. It was concluded that patients contaminated with Covid-19 had oral and maxillofacial clinical manifestations that may include ulcerations, inflammation in the oropharynx, retromandibular edema, fungal infections, xerostomia, anosmia, and ageusia.
References
1. Al-Khanati NM, Riad A, Sahloul ME, Klugar M. Aphthous-like stomatitis of Covid-19 patients: case report and review of evidence. Braz. J. Oral Sci. 2020 Nov. 4;19:e201354.
2. Capocasale G, Nocini R, Faccioni P, Donadello D, Bertossi D, Albanese M, et al. How to deal with coronavirus disease 2019: A comprehensive narrative review about oral involvement of the disease. Clin Exp Dent Res. 2021 Feb;7(1):101-108
3. Penoni DC. O novo coronavirus e a viralização da prevenção. Rev Nav Odontol. 2020; 47(1): 5-6
4. Braga DRA, Saintrain MVL, Rodrigues DM, Bezerra CB, Martins MGA. Condições de saúde bucal em pessoas acometidas por Covid-19. J. Health Biol Sci. 2021;9(1):1-8.
5. Etemad-Moghadam S, Alaeddini M. Is SARS-CoV-2 an Etiologic Agent or Predisposing Factor for Oral Lesions in Covid-19 Patients? A Concise Review of Reported Cases in the Literature. Int J Dent. 2021 May 18;2021:6648082
6. López LAO, Leon LAM, Ramirez DFP, Rascón JFL, Díaz LAC. Papel de los tejidos orales durante la infección por SARS-CoV-2. Revista ADM. México. 78 (3): 167-175. 2021.
7. Chawla J. Oral manifestations associated with Covid-19 disease: An observational cross-sectional study. Journal of Oral Biology and Craniofacial Research. 2022;12 (2): 279–283.
8. Parra–Sanabria EA, Bermúdez MB, Vega CPP, Jiménez AR. Manifestaciones orales y maxilofaciales asociadas a la Covid-19. Revisión de la literatura. Acta Odont Col. 2020; 10:60-80.
9. Moraes MF, Natalino YR, Holanda AF, Souza Sobrinho HF, Sarmento LC, Gomes APM, et al. Oral and cutaneous manifestations of Covid-19 in pediatric patients. RGO, Rev Gaúch Odontol. 2021;69:e2021005
10. Amorim Dos Santos J, Normando AGC, Carvalho da Silva RL, Acevedo AC, De Luca Canto G, Sugaya N, Santos-Silva AR, Guerra ENS. Oral Manifestations in Patients with Covid-19: A 6-Month Update. J Dent Res. 2021 Nov;100(12):1321-1329
11. Brandini DA, Takamiya AS, Thakkar P, Schaller S, Rahat R, Naqvi AR. Covid-19 and oral diseases: Crosstalk, synergy or association? Rev Med Virol. 2021 Nov;31(6):e2226
12. Monje Gil Florencio, Cebrián Carretero José Luis, López-Cedrún Cembranos José Luis, Redondo Alamillos Marta, Valdés Beltrán Andrés, Almeida Parra Fernando et al . Manejo de pacientes en cirugía oral y maxilofacial durante el periodo de crisis y de control posterior de la pandemia de Covid-19. Rev. Esp. Cirug. Oral y Maxilofac., 2020; 42 (2): 51-59.
13. Iranmanesh B, Khalili M, Amiri R, Zartab H, Aflatoonian M. Oral manifestations of Covid-19 disease: A review article. Dermatol Ther. 2021 Jan;34(1):e14578
14. Orellana-Centeno JE, Castillo VM, Sotelo RNG. Generalidades, manejos, cuidados y manifestaciones clínicas del SARS-CoV-2. Revista ADM. 2020; 77 (3): 153-155.
15. El Kady DM, Gomaa EA, Abdella WS, Ashraf Hussien R, Abd ElAziz RH, Khater AGA. Oral manifestations of Covid-19 patients: An online survey of the Egyptian population. Clin Exp Dent Res. 2021 Oct;7(5):852-860.
16. Maciel PP, Martelli Júnior H, Martelli DRB, Machado RA, Andrade PV, Perez DEC, et al. Covid-19 pandemic: oral repercussions and its possible impact on oral health. Pesqui Bras Odontopediatria Clín Integr. 2020; 20(supp1):e0138
17. Tavares NCSA, Santos EM, Bussadori SK, Imparato JCP, Rezende KM. Sinais e Sintomas de Manifestações Orais e Cutâneas em Crianças Com Covid-19: Revisão Narrativa. Research, Society and Development. 2021; 10 (10): e258101018515.
18. Halboub E, Al-Maweri SA, Alanazi RH, Qaid NM, Abdulrab S. Orofacial manifestations of Covid-19: a brief review of the published literature. Braz Oral Res. 2020 Oct 30;34:e124.
19. Pitak-Arnnop P, Meningaud JP, Sirintawat N, Subbalekha K, Auychai P, Iamaroon A, O-Charoenrat P, Suntorntham S, Messer-Peti R, Neff A. A German AWMF's S2e/realist synthesis and meta-narrative snapshot of craniomaxillofacial manifestations in Covid-19 patients: Rapid living update on 1 January 2021. J Stomatol Oral Maxillofac Surg. 2022 Feb;123(1):64-73.
20. Santos SV, Freitas IDP, Senna SFM, Rocha LPC, Armomino SAF. Manifestações orais do Covid-19: uma breve revisão de literatura. Rev. Odontol. Araçatuba. 2021; 42(3): 50-55.
21. Elamrousy WAH, Nassar M, Issa DR. Prevalence of Oral Lesions in Covid-19 Egyptian Patients. J Int Soc Prev Community Dent. 2021 Nov 30;11(6):712-720
22. Amacio AM, Souza LC, Silva EGC, Lima KC, Silveira EJD. Implicações orais e maxilofaciais da Covid-19: uma revisão integrativa. HOLOS. 2021; 3: 1–19
23. Nejabi MB, Noor NAS, Raufi N, Essar MY, Ehsan E, Shah J, Shah A, Nemat A. Tongue ulcer in a patient with Covid-19: a case presentation. BMC Oral Health. 2021 May 20;21(1):273
24. Natto ZS, Afeef M, Khalil D, Kutubaldin D, Dehaithem M, Alzahrani A, Ashi H. Characteristics of Oral Manifestations in Symptomatic Non-Hospitalized Covid-19 Patients: A Cross-Sectional Study on a Sample of the Saudi Population. Int J Gen Med. 2021 Dec 10;14:9547-9553.
25. Reis VP, Bezerra AR, Maia ABP, Marques LC, Conde DC. An integrative review of oral manifestations in patients with Covid-19: signs directly related to SARS-CoV-2 infection or secondary findings? Int J Dermatol. 2022 Mar;61(3):278-290.
26. Amorim dos Santos J, Normando AGC, Carvalho da Silva, RL, Acevedo AC, De Luca Canto G, Sugaya N, et al. Oral manifestations in patients with Covid-19: a living systematic review." Journal of dental research.2021; 100 (2): 141-154.
27. Riad A, Kassem I, Hockova B, Badrah M, Klugar M. Halitosis in Covid-19 patients. Spec Care Dentist.2020; 41(2):282-285.
28. Sinadinos A, Shelswell J. Oral ulceration and blistering in patients with Covid-19. Evid Based Dent. 2020; 21(2):49
29. Ettinger R, Marchini L, Zwetchkenbaum S. The Impact of Covid-19 on the Oral Health of Patients with Special Needs. Dent Clin North Am. 2022 Apr;66(2):181-194
30. Samaranayake LP, Fakhruddin KS, Ngo HC, Bandara HMNM, Leung YY. Orofacial Mycoses in Coronavirus Disease-2019 (Covid-19): A Systematic Review. Int Dent J. 2022 Oct;72(5):607-620.
2. Capocasale G, Nocini R, Faccioni P, Donadello D, Bertossi D, Albanese M, et al. How to deal with coronavirus disease 2019: A comprehensive narrative review about oral involvement of the disease. Clin Exp Dent Res. 2021 Feb;7(1):101-108
3. Penoni DC. O novo coronavirus e a viralização da prevenção. Rev Nav Odontol. 2020; 47(1): 5-6
4. Braga DRA, Saintrain MVL, Rodrigues DM, Bezerra CB, Martins MGA. Condições de saúde bucal em pessoas acometidas por Covid-19. J. Health Biol Sci. 2021;9(1):1-8.
5. Etemad-Moghadam S, Alaeddini M. Is SARS-CoV-2 an Etiologic Agent or Predisposing Factor for Oral Lesions in Covid-19 Patients? A Concise Review of Reported Cases in the Literature. Int J Dent. 2021 May 18;2021:6648082
6. López LAO, Leon LAM, Ramirez DFP, Rascón JFL, Díaz LAC. Papel de los tejidos orales durante la infección por SARS-CoV-2. Revista ADM. México. 78 (3): 167-175. 2021.
7. Chawla J. Oral manifestations associated with Covid-19 disease: An observational cross-sectional study. Journal of Oral Biology and Craniofacial Research. 2022;12 (2): 279–283.
8. Parra–Sanabria EA, Bermúdez MB, Vega CPP, Jiménez AR. Manifestaciones orales y maxilofaciales asociadas a la Covid-19. Revisión de la literatura. Acta Odont Col. 2020; 10:60-80.
9. Moraes MF, Natalino YR, Holanda AF, Souza Sobrinho HF, Sarmento LC, Gomes APM, et al. Oral and cutaneous manifestations of Covid-19 in pediatric patients. RGO, Rev Gaúch Odontol. 2021;69:e2021005
10. Amorim Dos Santos J, Normando AGC, Carvalho da Silva RL, Acevedo AC, De Luca Canto G, Sugaya N, Santos-Silva AR, Guerra ENS. Oral Manifestations in Patients with Covid-19: A 6-Month Update. J Dent Res. 2021 Nov;100(12):1321-1329
11. Brandini DA, Takamiya AS, Thakkar P, Schaller S, Rahat R, Naqvi AR. Covid-19 and oral diseases: Crosstalk, synergy or association? Rev Med Virol. 2021 Nov;31(6):e2226
12. Monje Gil Florencio, Cebrián Carretero José Luis, López-Cedrún Cembranos José Luis, Redondo Alamillos Marta, Valdés Beltrán Andrés, Almeida Parra Fernando et al . Manejo de pacientes en cirugía oral y maxilofacial durante el periodo de crisis y de control posterior de la pandemia de Covid-19. Rev. Esp. Cirug. Oral y Maxilofac., 2020; 42 (2): 51-59.
13. Iranmanesh B, Khalili M, Amiri R, Zartab H, Aflatoonian M. Oral manifestations of Covid-19 disease: A review article. Dermatol Ther. 2021 Jan;34(1):e14578
14. Orellana-Centeno JE, Castillo VM, Sotelo RNG. Generalidades, manejos, cuidados y manifestaciones clínicas del SARS-CoV-2. Revista ADM. 2020; 77 (3): 153-155.
15. El Kady DM, Gomaa EA, Abdella WS, Ashraf Hussien R, Abd ElAziz RH, Khater AGA. Oral manifestations of Covid-19 patients: An online survey of the Egyptian population. Clin Exp Dent Res. 2021 Oct;7(5):852-860.
16. Maciel PP, Martelli Júnior H, Martelli DRB, Machado RA, Andrade PV, Perez DEC, et al. Covid-19 pandemic: oral repercussions and its possible impact on oral health. Pesqui Bras Odontopediatria Clín Integr. 2020; 20(supp1):e0138
17. Tavares NCSA, Santos EM, Bussadori SK, Imparato JCP, Rezende KM. Sinais e Sintomas de Manifestações Orais e Cutâneas em Crianças Com Covid-19: Revisão Narrativa. Research, Society and Development. 2021; 10 (10): e258101018515.
18. Halboub E, Al-Maweri SA, Alanazi RH, Qaid NM, Abdulrab S. Orofacial manifestations of Covid-19: a brief review of the published literature. Braz Oral Res. 2020 Oct 30;34:e124.
19. Pitak-Arnnop P, Meningaud JP, Sirintawat N, Subbalekha K, Auychai P, Iamaroon A, O-Charoenrat P, Suntorntham S, Messer-Peti R, Neff A. A German AWMF's S2e/realist synthesis and meta-narrative snapshot of craniomaxillofacial manifestations in Covid-19 patients: Rapid living update on 1 January 2021. J Stomatol Oral Maxillofac Surg. 2022 Feb;123(1):64-73.
20. Santos SV, Freitas IDP, Senna SFM, Rocha LPC, Armomino SAF. Manifestações orais do Covid-19: uma breve revisão de literatura. Rev. Odontol. Araçatuba. 2021; 42(3): 50-55.
21. Elamrousy WAH, Nassar M, Issa DR. Prevalence of Oral Lesions in Covid-19 Egyptian Patients. J Int Soc Prev Community Dent. 2021 Nov 30;11(6):712-720
22. Amacio AM, Souza LC, Silva EGC, Lima KC, Silveira EJD. Implicações orais e maxilofaciais da Covid-19: uma revisão integrativa. HOLOS. 2021; 3: 1–19
23. Nejabi MB, Noor NAS, Raufi N, Essar MY, Ehsan E, Shah J, Shah A, Nemat A. Tongue ulcer in a patient with Covid-19: a case presentation. BMC Oral Health. 2021 May 20;21(1):273
24. Natto ZS, Afeef M, Khalil D, Kutubaldin D, Dehaithem M, Alzahrani A, Ashi H. Characteristics of Oral Manifestations in Symptomatic Non-Hospitalized Covid-19 Patients: A Cross-Sectional Study on a Sample of the Saudi Population. Int J Gen Med. 2021 Dec 10;14:9547-9553.
25. Reis VP, Bezerra AR, Maia ABP, Marques LC, Conde DC. An integrative review of oral manifestations in patients with Covid-19: signs directly related to SARS-CoV-2 infection or secondary findings? Int J Dermatol. 2022 Mar;61(3):278-290.
26. Amorim dos Santos J, Normando AGC, Carvalho da Silva, RL, Acevedo AC, De Luca Canto G, Sugaya N, et al. Oral manifestations in patients with Covid-19: a living systematic review." Journal of dental research.2021; 100 (2): 141-154.
27. Riad A, Kassem I, Hockova B, Badrah M, Klugar M. Halitosis in Covid-19 patients. Spec Care Dentist.2020; 41(2):282-285.
28. Sinadinos A, Shelswell J. Oral ulceration and blistering in patients with Covid-19. Evid Based Dent. 2020; 21(2):49
29. Ettinger R, Marchini L, Zwetchkenbaum S. The Impact of Covid-19 on the Oral Health of Patients with Special Needs. Dent Clin North Am. 2022 Apr;66(2):181-194
30. Samaranayake LP, Fakhruddin KS, Ngo HC, Bandara HMNM, Leung YY. Orofacial Mycoses in Coronavirus Disease-2019 (Covid-19): A Systematic Review. Int Dent J. 2022 Oct;72(5):607-620.
Downloads
Published
2023-06-02
Issue
Section
Literature Reviews
How to Cite
Oral And Maxillofacial Manifestations Of Covid-19 - Integrative Literature Review: Manifestações Orais E Maxilofaciais Da Covid-19 – Revisão Integrativa Da Literatura. (2023). Naval Dental Jounal, 50(1), 34-41. https://doi.org/10.29327/25149.50.1-6
